Human Prostaglandin E Synthase 3, PTGES3 ELI
3,140.00 ₪
Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway.
Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed: 18682561, PubMed: 10377395, PubMed: 12672824, PubMed: 12460774, PubMed: 10869354, PubMed: 12244105).
Plays a key role in inflammation response, fever and pain (By similarity).
Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed: 12244105, PubMed: 12672824).
In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed: 12672824).
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