Human Prostaglandin F2-alpha Receptor, PTGFR ELI

Receptor for prostaglandin F2-alpha (PGF2-alpha).

The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.