Human Protein Arginine N-methyltransferase 2, PRMT2 ELI

Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4.

Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation.

Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation.

Enhances PGR, PPARG, RARA-mediated transactivation.

May inhibit NF-kappa-B transcription and promote apoptosis.

Represses E2F1 transcriptional activity (in a RB1-dependent manner).

May be involved in growth regulation.