Human Protein Jtb, JTB ELI

Required for normal cytokinesis during mitosis.

Plays a role in the regulation of cell proliferation.

May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.

The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.

Increases AURKB activity.

Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).