Human Protein O-GlcNAcase,OGA ELI

[Isoform 1]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins.

Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210).

Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).

{ECO:0000269|PubMed:11148210, ECO:0000269|PubMed:11788610, ECO:0000269|PubMed:20673219, ECO:0000269|PubMed:22365600, ECO:0000269|PubMed:24088714}.; [Isoform 3]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins.

Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.

{ECO:0000269|PubMed:20673219}.