Human Protein Patched Homolog 1, PTCH1 ELI

Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH).

Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal.

Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.