Human Protein Phosphatase 1 Regulatory Subunit 1A, PPP1R1A ELI

Inhibitor of protein-phosphatase 1.

This protein may be important in hormonal control of glycogen metabolism.

Hormones that elevate intracellular cAMP increase I-1 activity in many tissues.

I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA.

Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B).

Does not inhibit type-2 phosphatases.