Human Protein Phosphatase 1B, PPM1B ELI

Enzyme with a broad specificity.

Dephosphorylates CDK2 and CDK6 in vitro.

Dephosphorylates PRKAA1 and PRKAA2.

Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'.

Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.