Human Protein Phosphatase 2A, PP2A ELI

Enzyme with a broad specificity.

Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.

Dephosphorylates PRKAA1 and PRKAA2.

Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.