Human Protein Phosphatase, Mg2+, Mn2+ Dependent 1D, PPM1D ELI

Involved in the negative regulation of p53 expression (PubMed: 23242139).

Required for the relief of p53-dependent checkpoint mediated cell cycle arrest.

Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed: 15870257, PubMed: 16311512).

Mediates MAPK14 dephosphorylation and inactivation (PubMed: 21283629).

Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity).