Human Protein Wnt-1,WNT1 ELI
3,140.00 ₪
Ligand for members of the frizzled family of seven transmembrane receptors (Probable).
Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:23499309, PubMed:26902720, PubMed:28528193, PubMed:23656646).
In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity).
Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity).
Has a role in osteoblast function, bone development and bone homeostasis (PubMed:23499309, PubMed:23656646).
{ECO:0000250|UniProtKB:P04426, ECO:0000269|PubMed:23499309, ECO:0000269|PubMed:23656646, ECO:0000269|PubMed:26902720, ECO:0000269|PubMed:28528193, ECO:0000305}.
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