Human Proteoglycan 4, PRG4 ELI

Plays a role in boundary lubrication within articulating joints.

Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.

Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.