Human Proto-oncogene tyrosine-protein kinase ROS,ROS1 ELI
3,140.00 ₪
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium.
May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway.
Mediates the phosphorylation of PTPN11, an activator of this pathway.
May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth.
Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology.
May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
{ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:16885344}.
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