Human Putative humanin peptide,MT-RNR2 ELI

Plays a role as a neuroprotective factor.

Protects against death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease.

Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol to mitochondria.

Binds to IGFBP3 and specifically blocks IGFBP3-induced cell death Induces chemotaxis of mononuclear phagocytes via FPR2.

Reduces the aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and acts by competitively inhibiting the access of FPRL1 to APP.

{ECO:0000269|PubMed:11371646, ECO:0000269|PubMed:11717357, ECO:0000269|PubMed:12732850, ECO:0000269|PubMed:14561895, ECO:0000269|PubMed:15153530}.