Human Rap1 GTPase-GDP dissociation stimulator 1,RAP1GDS1 ELI

Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein (PubMed:1549351, PubMed:11948427).

Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake (PubMed:24349085).

{ECO:0000269|PubMed:11948427, ECO:0000269|PubMed:1549351, ECO:0000269|PubMed:24349085}.