Human Ras-related Protein Rab-10, RAB10 ELI

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed: 21248164).

Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed: 21248164).

That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (PubMed: 21248164).

Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity).

In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity).

Plays also a specific role in asymmetric protein transport to the plasma membrane (PubMed: 16641372).

In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity).

In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (PubMed: 16641372).

May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity).

May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (PubMed: 23263280).

Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (PubMed: 30398148).

When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis (PubMed: 30398148).

(Microbial infection) Upon Legionella pneumophila infection promotes endoplasmic reticulum recruitment and bacterial replication.

Plays a role in remodeling the Legionella-containing vacuole (LCV) into an endoplasmic reticulum-like vacuole.