Human Ras-related Protein Rab-27A, RAB27A ELI

Small GTPase which cycles between active GTP-bound and inactive GDP-bound states.

In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed: 30771381).

Plays a role in cytotoxic granule exocytosis in lymphocytes.

Required for both granule maturation and granule docking and priming at the immunologic synapse.