Human Replication Initiator 1, REPIN1 ELI

Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication.

Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone.

Facilitates DNA bending.