Human Reticulocalbin 3, RCN3 ELI

Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed: 16433634, PubMed: 28939891).

Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity).

By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity).

Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (PubMed: 28939891).

This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (PubMed: 16433634).