Human Retinoic Acid Receptor Beta, RARB ELI
3,140.00 ₪
Receptor for retinoic acid.
Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes.
The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5.
In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (PubMed: 12554770).
The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (PubMed: 29021580).
In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
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