Human Retrotransposon-derived Protein Peg10, PEG10 ELI

Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis.

May also have a role in cell growth promotion and hepatoma formation.

Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ACVRL1.

When overexpressed, induces the formation of cellular extension, such as filipodia in association with ACVRL1.

Involved at the immediate early stage of adipocyte differentiation (By similarity).

May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity).