Human Rho-associated,ROCK1 ELI

Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579).

Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579, PubMed:23093407, PubMed:23355470).

Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941).

Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714).

Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity).

Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962).

Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity).

Plays a role in terminal erythroid differentiation (PubMed:21072057).

Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity).

Promotes keratinocyte terminal differentiation (PubMed:19997641).

Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity).

May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity).

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