Human Rho Gtpase-activating Protein 9, ARHGAP9 ELI

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA.

Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix.

Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.