Human Rho Guanine Nucleotide Exchange Factor 1, ARHGEF1 ELI

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed: 9641915, PubMed: 9641916).

Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed: 9641915, PubMed: 9641916, PubMed: 8810315, PubMed: 30521495).

Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed: 9641916).

This GEF activity is inhibited by binding to activated GNA12 (PubMed: 9641916).

Mediates angiotensin-2-induced RhoA activation (PubMed: 20098430).