Human Rho-related GTP-binding Protein Rhob(Rhob), RHOB ELI

Mediates apoptosis in neoplastically transformed cells after DNA damage.

Not essential for development but affects cell adhesion and growth factor signaling in transformed cells.

Plays a negative role in tumorigenesis as deletion causes tumor formation.

Involved in intracellular protein trafficking of a number of proteins.

Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes.

Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.

Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis.

Required for genotoxic stress-induced cell death in breast cancer cells.