Human Ribonuclease Pancreatic, RNASE1 Primacu™ ELI
3,970.00 ₪
RNase A, also known as ribonuclease A and RNASE1, belongs to ribonuclease A superfamily.
It is a pancreatic-type of secretory ribonuclease.
RNase A is a basic protein and its many positive charges are consistent with its binding to RNA (a poly-anion).
More generally, RNase A is unusually polar or, rather, unusually lacking in hydrophobic groups, especially aliphatic ones.
As an endonuclease, RNase A cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases.
It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0.
RNase A is monomeric and more commonly acts to degrade ds-RNA over ss-RNA.
Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
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