Human RIO Kinase 3,RIOK3 ELI
3,140.00 ₪
Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses.
May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708).
Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883).
Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502).
May play a role in the biogenesis of the 40S ribosomal subunit.
Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843).
{ECO:0000269|PubMed:19557502, ECO:0000269|PubMed:22418843, ECO:0000269|PubMed:24807708, ECO:0000269|PubMed:25865883}.
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