Human RNA-binding Protein Ews, EWSR1 ELI

Might normally function as a transcriptional repressor.

EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process.

They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex.

They may also contribute to an aberrant activation of the fusion protein target genes.