Human Ryanodine Receptor 2, RYR2 ELI

Calcium Channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction.

Aberrant Channel activation can lead to cardiac arrhythmia.

In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium Channel CACNA1C.

The calcium Channel activity is modulated by formation of heterotetramers with RYR3.

Required for cellular calcium ion homeostasis.

Required for embryonic heart development.