Human Scavenger Receptor Class B Member 1, SCARB1 ELI

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed: 12016218, PubMed: 12519372, PubMed: 21226579).

Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed: 26965621).

Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL.

May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed: 12016218).

(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed: 12356718, PubMed: 12913001, PubMed: 18000990).

Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed: 12356718).

Mediates uptake of M.fortuitum, E.coli and S.aureus (PubMed: 16020694).