Human Secreted Frizzled Related Protein 3, SFRP3 ELI

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts.

They have a role in regulating cell growth and differentiation in specific cell types.

SFRP3/FRZB appears to be involved in limb skeletogenesis.

Antagonist of Wnt8 signaling.

Regulates chondrocyte maturation and long bone development.