Human Semaphorin 4C, SEMA4C ELI

Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling.

PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'.

Required for normal brain development, axon guidance and cell migration (By similarity).

Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.