Human Semaphorin 4D, SEMA4D ELI

Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed: 20877282).

Regulates GABAergic synapse development (By similarity).

Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity).

Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed: 19788569).

Promotes the migration of cerebellar granule cells (PubMed: 16055703).

Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed: 8876214).

Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed: 16055703).