Human Semaphorin 7A, SEMA7A ELI

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses.

Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3.

Promotes production of proinflammatory cytokines by monocytes and macrophages.

Plays an important role in modulating inflammation and T-cell-mediated immune responses.

Promotes axon growth in the embryonic olfactory bulb.

Promotes attachment, spreading and dendrite outgrowth in melanocytes.