Human Septin-7, SEPT7 ELI

Filament-forming cytoskeletal GTPase.

Required for normal organization of the actin cytoskeleton.

Required for normal progress through mitosis.

Involved in cytokinesis.

Required for normal association of CENPE with the kinetochore.

Plays a role in ciliogenesis and collective cell movements.

Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed: 25588830).