Human Serine Threonine-protein Kinase Lmtk3, LMTK3 ELI

Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation.

May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).