Human Serine, Threonine-protein Kinase Nek3, NEK3 ELI

Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules.

Regulates microtubule acetylation in neurons.

Contributes to prolactin-mediated phosphorylation of PXN and VAV2.

Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.