Human Serine, Threonine-protein Kinase Plk3, PLK3 ELI

Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly.

Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains.

Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1.

Involved in cell cycle regulation: required for entry into S phase and cytokinesis.

Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis.

Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia.

Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73.

Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis.

Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint.

Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions.

Phosphorylates HIF1A and JUN is response to hypoxia.

Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium.

Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1.

May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.