Human SH3 Domain Containing GRB2 Like Endophilin B1,SH3GLB1 ELI

May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144).

Required for coatomer-mediated retrograde transport in certain cells (By similarity).

May recruit other proteins to membranes with high curvature.

May promote membrane fusion (PubMed:11604418).

Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588).

Isoform 1 acts proapoptotic in fibroblasts (By similarity).

Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy.

Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140).

Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542).

Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).

Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity).

{ECO:0000250|UniProtKB:Q9JK48, ECO:0000269|PubMed:11604418, ECO:0000269|PubMed:15452144, ECO:0000269|PubMed:17891140, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:21068542}.