Human Short Transient Receptor Potential Channel 5, TRPC5 ELI

Thought to form a receptor-activated non-selective calcium permeant cation Channel.

Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.

Has also been shown to be calcium-selective (By similarity).

May also be activated by intracellular calcium store depletion.

Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity).