Human Signal Peptide, Cub and EGF-like Domain-containing Protein 3, SCUBE3 ELI

Binds to TGFBR2 and activates TGFB signaling.

In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.