Human snail homolog 2,SNAI2 ELI

Transcriptional repressor that modulates both activator-dependent and basal transcription.

Involved in the generation and migration of neural crest cells.

Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity).

Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells.

In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription.

Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes.

Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes.

Represses E-Cadherin/CDH1 transcription via E-box elements.

Involved in osteoblast maturation.

Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts.

Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts.

Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.

{ECO:0000250, ECO:0000269|PubMed:10866665, ECO:0000269|PubMed:11912130, ECO:0000269|PubMed:15734731, ECO:0000269|PubMed:16707493, ECO:0000269|PubMed:19756381, ECO:0000269|PubMed:21182836}.