Human Sodium Channel Protein Type 11 Subunit Alpha, SCN11A ELI

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes.

Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient.

It is a tetrodotoxin-resistant sodium channel isoform.

Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.