Human solute carrier family 4 member 5,SLC4A5 ELI

Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1.

May have a housekeeping function in regulating the pH of tissues in which it is expressed.

May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes.

Also may be important in protecting the renal paranchyma from alterations in urine pH.

{ECO:0000250|UniProtKB:Q6RI88, ECO:0000269|PubMed:11788353, ECO:0000269|PubMed:11997242, ECO:0000269|PubMed:12388414}.