Human Sorting Nexin 2, SNX2 ELI
3,140.00 ₪
Involved in several stages of intracellular trafficking.
Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed: 16179610).
Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed: 17101778).
The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling.
The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable).
Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed: 23085988).
Required for retrograde endosome-to-TGN transport of TGN38 (PubMed: 20138391).
Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed: 20604901).
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