Human Sp100 Nuclear Antigen,Sp100 ELI

Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis.

Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962.

Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905.

Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion.

Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening.

May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis.

Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.

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