Human Spexin, C12ORF39 ELI

Plays a role as a central modulator of cardiovascular and renal function and nociception.

Plays also a role in energy metabolism and storage.

Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity).

[Spexin-1]: Acts as a ligand for galanin receptors GALR2 and GALR3 (PubMed: 17284679, PubMed: 24517231).

Intracerebroventricular administration of the Peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis.

Intraventricular administration of the Peptide induces antinociceptive activity.

Also induces contraction of muscarinic-like stomach smooth muscles.

Intraperitoneal administration of the Peptide induces a reduction in food consumption and body weight.

Inhibits long chain fatty acid uptake into adipocytes (By similarity).

[Spexin-2]: Intracerebroventricular administration of the Peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate.

Intraventricular administration of the Peptide induces antinociceptive activity (By similarity).