Human Sphingosine-1-phosphate lyase 1,SGPL1 ELI
3,140.00 ₪
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine.
Elevates stress-induced ceramide production and apoptosis (PubMed:11018465, PubMed:14570870, PubMed:24809814, PubMed:28165339).
Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts.
Involved in the regulation of pro-inflammatory response and neutrophil trafficking.
Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity).
Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity).
{ECO:0000250|UniProtKB:Q8R0X7, ECO:0000250|UniProtKB:Q9V7Y2, ECO:0000269|PubMed:11018465, ECO:0000269|PubMed:14570870, ECO:0000269|PubMed:24809814, ECO:0000269|PubMed:28165339}.
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