Human Sphingosine 1-phosphate receptor 2,S1PR2 ELI

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617).

S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617).

When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617).

Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251).

Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity).

{ECO:0000250|UniProtKB:P47752, ECO:0000269|PubMed:10617617, ECO:0000269|PubMed:29453251}.