Human Splicing Factor 3B Subunit 1, SF3B1 ELI

Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed: 27720643).

SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA.

Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed: 12234937).

Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity).

May also be involved in the assembly of the 'E' complex (PubMed: 10882114).

Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed: 15146077).